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美丽姑娘玛丽·梅森（凯瑟琳·伊莎贝尔 Katharine Isabelle 饰）是一所医学院的在读学生，她只身一人在外求学，对爱情一类的全然没有兴趣，闲暇时分独自在家做做模拟手术打发时光，所取得的成绩得到授课教授的盛赞。虽然还未取得行医执照，但玛丽显然已无法抑制走上手术台的勃勃欲望。偶然机缘，她进入一个地下世界，做了两起小手术。成就感和丰厚的报酬令她兴奋不已。就在此时，她接到教授的邀请，进入一个私人聚会，却遭遇了最不堪回首的夜晚。这一事件让玛丽内心深处的黑暗彻底释放，对恶人的憎恶，对手术的渴望，全部裹挟在一起，踏上了亵渎肉体和造物的旅途…… 本片荣获2012年尖叫电影节最佳女主角奖（Katharine Isabelle）、最佳剧本奖、最佳导演奖和最佳化妆奖。
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